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In addition, the FDA has issued an emergency use authorization (EUA) for the oral antiviral molnupiravir (Lagevrio), which can be used for treatment of patients with mild to moderate illness who are at risk for severe illness. For more information about nirmatrelvir and ritonavir (Paxlovid), please see the FDA Fact Sheet for Healthcare Providers and the approved label. Department of Health and Human Services will continue to be available to ensure continued access for adults, as well as treatment of eligible children ages 12-18 who are not covered by the approval. Paxlovid manufactured and packaged under the emergency use authorization (EUA) and distributed by the U.S. The FDA has also approved the oral antiviral nirmatrelvir with ritonavir (Paxlovid) for the treatment of mild-to-moderate COVID-19 in adults who are at high risk for progression to severe disease. The FDA has approved the intravenous antiviral medication remdesivir (Veklury) for the treatment of COVID-19 in adults and pediatric patients. Clinicians should consider offering therapeutics and monitoring closely patients with risk factors for severe illness. ( 37,38) Test to treat strategies may allow for timely diagnosis and treatment of patients who are at risk for severe disease. For these patients, therapeutics, such as antivirals, have been shown to significantly decrease the risk of hospitalization and death, and outcomes are improved if therapeutics are started within the first days of illness. Some patients with mild to moderate COVID-19 may be at increased risk for progression to severe COVID-19. Patients can also be instructed on efforts they can take to reduce transmission and symptoms that indicate the need for additional medical attention. These patients can benefit from supportive care and symptomatic treatment, including antipyretics, analgesics, and antitussives. Most patients with COVID-19 experience asymptomatic or mild illness that does not warrant medical intervention, or mild to moderate illness that can be managed in the outpatient setting.